Institute of Process Research and Development

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Journals

2017

112. K. E. Jolley, W. Nye, C. González Niño. N. Kapur, A. Rabion, K. Rossen and A. J. Blacker, “Highly productive continuous flow synthesis of di- and tripeptides in water” ORG. PROC. RES. DEV., 2017, Just accepted manuscript (DOI: 10.1021/acs.oprd.7b00214)

111. R. Fogarty, R. Rowe, R. P. Matthews, M. Clough, C. Ashworth, A. Brandt, P. J. Corbett., R. Palgrave, E. F. Smith, R. Bourne, T. W. Chamberlain, P. Thompson, P. Hunt amd K. R. J. Lovelock, "FDIONIC18 Atomic charges of sulfur in ionic liquids: experiments and calculations" FARADAY DISCUSS., 2017, Accepted Manuscript (DOI: 10.1039/C7FD00135J)

110. S. T. Skowron, T. W. Chamberlain, J. Biskupek, U. Kaiser, E. Besley and A. N. Khlobystov, “Chemical reactions of molecules promoted and simultaneously imaged by the electron beam in transmission electron microscopy” ACC. CHEM. RES., 2017, 50, 1797-1807 (DOI: 10.1021/acs.accounts.7b00078)

109. T. T. H. Nguyen, I. Rosbottom, I. Marziano, R. B. Hammond and K. J. Roberts “Crystal Morphology and Interfacial stability of RS-Ibruprofen in relation to its molecular and synthonic structure” CRYST. GROWTH DES. 2017, 17, 3088-3099 (DOI: 10.1021/acs.cgd.6b01878)

108. M. R. Chapman, M. H. Kwan, G. King, K. E. Jolley, M. Hussain, S. Hussain, I. E. Salama, C. Gonzalez Nino, L. A. Thompson, M. E. Bayana, A. Clayton, B. N. Nguyen, N. J. Turner, N. Kapur and A. J. Blacker, "A simple and versatile laboratory scale CSTR for multiphasic continuous-flow chemistry and long residence times" ORG. PROC. RES. DEV., 2017, Just accepted manuscript (DOI: 10.1021/acs.oprd.7b00173)

107. S. P. Marsden, P. C. McGowan, R. Lanaro and A. J. Blacker, "Preparation and use of transition metal complexes" WO2017103623 (A1), 2017

106. R.Fogarty, R. Rowe, R. P. Matthews, M. Clough, C. Ashworth, A. Brandt, P. J. Corbett., R. Palgrave, E. F. Smith, R. Bourne, T. W. Chamberlain, P. Thompson, P. Hunt amd K. R. J. Lovelock, "FDIONIC18 Atomic charges of sulfur in ionic liquids: experiments and calculations" FARADAY DISCUSS., 2017, Accepted Manuscript (DOI: 10.1039/C7FD00135J)

105. A. S. Sinitsa, T. W. Chamberlain, T. Zoberbier, I. V. Lebedeva, A. M. Popov, A. A. Knizhnik, R. L. McSweeney, J. Biskupek, U. Kaiser and A. N. Khlobystov, “Formation of Nickel Clusters Wrapped in Carbon Cages: Toward New Endohedral Metallofullerene Synthesis” NANO LETT., 17, 1082-1089 (DOI:10.1021/acs.nanolett.6b04607)

104. T. W. Chamberlain, J. Biskupek, S. T. Skowron, A. V. Markevich, S. Kurasch, O. Reimer, K. E. Walker, G. A. Rance, X. Feng, K. Müllen, A. Turchanin, M. A. Lebedeva, A. G. Majouga, V. G. Nenajdenko, U. Kaiser, E. Besley and A. N. Khlobystov, “Stop-Frame Filming and Discovery of Reactions at the Single-Molecule Level by Transmission Electron Microscopy.” ACS NANO, 2017, 11, 2509-2520 (DOI:10.1021/acsnano.6b08228)

103. Simon Doherty, Julian G. Knight, Tom Backhouse, Einas Abood, Hind Alshaikh, Ian J. S. Fairlamb, Richard Bourne, Thomas W. Chamberlain and Rebecca Stones, “Highly efficient aqueous phase chemoselective hydrogenation of α,β-unsaturated aldehydes, ketones, esters and nitriles catalysed by palladium nanoparticles stabilised with phosphine-decorated polymer immobilised ionic liquids.” GREEN CHEM., 2017, 19, 1635-1641  (DOI: 10.1039/C6GC03528K)

102. Katharina G. Hugentobler, Marcello Rasparini, Lisa A. Thompson, Katherine E. Jolley, A. John Blacker and Nicholas J. Turner “Comparison of a batch and flow approach for the lipase catalysed resolution of a cyclopropanecarboxylate ester; a key building block for the synthesis of ticagrelor.” ORG. PROCESS RES. DEV., 2017, 21, 195-199 (DOI:10.1021/acs.oprd.6b00346)

101. Ilias K. Stamatiou and Frans L. Muller, “Determination of mass transfer resistances of fast reactions in three-phase mechanically agitated slurry reactors.” AIChE J., 2017, 63, 273-282 (DOI:10.1002/aic.15540)

100. Christopher A. Hone, Nicholas Holmes, Geoffrey R. Akien, Richard A. Bourne and Frans L. Muller, “Rapid multistep kinetic model generation from transient flow data.” REACT. CHEM. ENG., 2017, 2, 103-108 (DOI: 10.1039/C6RE00109B)

2016

99.  M. A. Lebedeva, T. W. Chamberlain, A. Thomas, B. E. Thomas, C. T. Stoppiello, E. Volkova, M. Suyetin and A. N. Khlobystov, “Chemical reactions at the graphitic step-edge: Changes in product distribution of catalytic reactions as a tool to explore the environment within carbon nanoreactors.” NANOSCALE, 2016, 8, 11727-11737 (DOI:10.1039/c6nr03360a)

98.  M. A. Lebedeva, T. W. Chamberlain, P. A. Scattergood, M. Delor, I. V. Sazanovich, E. S. Davies, M. Suyetin, E. Besley, M. Schröder, J. A. Weinstein and A. N. Khlobystov, “Stabilising the lowest energy charge-separated state in a {metal chromophore-fullerene} assembly: A tuneable panchromatic absorbing donor-acceptor triad.” CHEM. SCI., 2016, 7, 5908-5921(DOI:10.1039/c5sc04271b)

97. Yuhan Zhao, Georgina King, Maria H. T. Kwan and A. John Blacker, "A mild and selective method for the catalytic hydrodeoxygenation of cyanurate activated phenols in multiphasic continuous flow." ORG. PROC. RES. DEV., 2016, 20, 2012-2018 (DOI: 10.1021/acs.oprd.6b00314)

96.   T. D. Turner, D. M. C. Corzo, D. Toroz, A. Curtis, M. M. Dos Santos, R. B. Hammond, X. Lai and K. J, Roberts “The influence of solution environment on the nucleation kinetics and crystallisability of para-aminobenzoic acid.” PHYS. CHEM. CHEM. PHYS., 2016, 18, 27507-27520 (DOI: 10.1039/C6CP04320H)

95. Akos Botos, Johannes Biskupek, Thomas W. Chamberlain, Graham A. Rance, Craig T. Stoppiello, Jeremy Sloan, Zheng Liu, Kazutomo Suenaga, Ute Kaiser and Andre N. Khlobystov, "Carbon nanotubes as electrically active nanoreactors for multi-step inorganic synthesis: sequential transformations of molecules to nanoclusters and nanoclusters to anaoribbons." J. AM. CHEM. SOC., 2016, 138, 8175-8183 (DOI: 10.1021/jacs.6b03633)

94. Tarn C. Johnston and Stephen P. Marsden, “Precious-metal-free heteroarylation of azlactones:direct synthesis of α-substituted amino acid derivatives.” ORG. LETT., 2016, 18, 5364-5367 (DOI: 10.1021/acs.org;ett.6b02731)

93. Asterios Gavriilidis, Achilleas Constantinou, Klaus Hellgardt, King Kuok (Mimi) Hii, Graham J. Hutchings, Gemma L. Brett, Simon Kuhn and Stephen P. Marsden, “Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries.” REACT. CHEM. ENG., 2016, 1, 595-612 (DOI: 10.1039/C6RE00155F)

92. Jacob R. Hauser, Hester A Beard, Mary E. Bayana, Katherine E. Jolley, Stuart L. Warriner and Robin S. Bon, "Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole." BEILSTEIN J. ORG. CHEM., 2016, 12, 2019-2025 (DOI: 10.3762/bjoc.12.189)

91. Simon Doherty, Julian G. Knight, Michael Carroll, Ashley Clemmet, Jack Ellison, Tom Backhouse, Nicholas Holmes, Lisa A. Thompson and Richard Bourne, “Efficient and selective oxidation of sulphides in batch and continuous flow using styrene-based polymer immobilised ionic liquid phase supported peroxotungstates.” RSC ADV., 2016, 6, 73118-73131 (DOI: 10.1039/C6RA11157B)

90. Maria A. Lebedeva, Thomas W. Chamberlain, Alice Thomas, Bradley E. Thomas, Craig T Stoppiello, Evgeniya Volkova, Mikhail Suyetin and Andrei N. Khlobystov, “ Chemical reactions at the graphitic step-edge: changes in product distribution of catalytic reactions as a tool to explore the environment within carbon nanoreactors.” Nanoscale, 2016, 8, 11727-11737 (DOI:10.1039/C6NR03360A)

89. Carlo Sambiagio, Rachel H. Munday, A. John Blacker, Stephen P. Marsden and Patrick C. McGowan, “Green alternative solvents for the copper-catalysed arylation of phenols and amides.” RSC ADV., 2016, 6, 70025-70032 (DOI: 10.1039/C6RA02265K)

88. Michael R. Chapman, Maria H. T. Kwan, Georgina E. King, Benjamin A. Kyffin, A. John Blacker, Charlotte E. Willans and Bao N. Nguyen, “Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions.” GREEN CHEM., 2016, 18, 4623-4627 (DOI: 10.1039/C6GC01601D)

87. Matthew J. Stirling, Joseph M. Mwansa, Gemma Sweeney, A. John Blacker and Michael I. Page, “The kinetics and mechanism of the organo-iridium catalysed racemisation of amines, ORG. BIOMOL. CHEM., 2016, 14, 7092-7098 (DOI: 10.1039/C6OB00884D)

86. Nicholas Holmes, Geoffrey R. Akien, A. John Blacker, Robert L. Woodward, Rebecca E. Meadows and Richard A. Bourne, “Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor.” REACT. CHEM. ENG., 2016, 1, 366-371 (DOI: 10.1039/C6RE00059B)

85.  Robert L. McSweeney, Thomas W. Chamberlain, Matteo Baldoni, Maria A. Lebedeva, E. Stephen Davies, Elena Besley and Andrei N. Khlobystov, “Direct measurement of electron transfer in nanoscale host-guest systems: metallocenes in carbon nanotubes.” CHEM. EUR. J. 2016, 22, 13540-13549 (DOI: 10.1002/chem.201602116)

84. Thilo Zoberbier, Thomas W. Chamberlain, Johannes Biskupek, Mikhail Suyetin, Alexander G. Majouga, Elena Besley, Ute Kaiser and Andrei N. Khlobystov, “Investigation of the interactions and bonding between carbon and group VIII metals at the atomic scale.” SMALL, 2016, 12, 1649-1657 (DOI: 10.1002/smll.201502210)

83. Michael R. Chapman, Susan E. Henkelis, Nikil Kapur, Bao N. Nguyen, and Charlotte E. Willans, "A Straightforward Electrochemical Approach to Imine- and Amine-bisphenolate Metal Complexes with Facile Control Over Metal Oxidation State." CHEMISTRYOPEN, 2016, 5, 331-356 (DOI: 10.1002/open.201600019)

82. Stephanie J. Lucas, Rianne M. Lord, Aida M. Basri, Simon A. Allison, Roger M. Phillips, John Blacker and Patrick C. McGowan, “Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes,” DALTON TRANS., 2016, 45, 6812-6815 (DOI: 10.1039/C6DT00186F)

81. Matthew J. Stirling Gemma Sweeney Kerry MacRory,  A. John Blacker and   Michael I. Page,The kinetics and mechanism of the organo-iridium-catalysed enantioselective reduction of imines,” ORG. BIOMOL. CHEM., 2016, 14, 3614-3622. (DOI: 10.1039/C6OB00245E)

80. Tarn C. Johnson and Stephen P. Marsden, "A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines," BEILSTEIN J. ORG. CHEM., 2016, 12, 1-4 (DOI: 10.3762/bjoc.12.1)

79. Nicholas Holmes, Geoffrey R. Akien, Robert J. D. Savage, Christian Stanetty, Ian R. Baxendale, A. John Blacker, B. A. Taylor, Robert L. Woodward, Rebecca E. Meadows and Richard A. Bourne, “Online quantitative mass spectroscopy for the rapid adaptive optimisation of automated flow reactors,” REACT. CHEM. ENG., 2016, 1, 96-100 (DOI: 10.1049/C5RE00083A)

78. Patricia Marcé, James Lynch, A. John Blacker and Jonathan M. J. Williams, “A mild hydration of nitriles catalysed by copper(II) acetate,” CHEM. COMMUN., 2016, 52, 1436-1438 (DOI: 10.1039/C5CC08714G)

77. Patricia Marcé, James Lynch, A. John Blacker and Jonathan M. J. Williams, “Conversion of nitroalkanes into carboxylic acids via iodide catalysis in water,” CHEM. COMMUN., 2016, 52, 1013-1016 (DOI:10.1039/C5CC08681G)

76. Philip C. Bulman Page, Mohamed M. Farah, Benjamin R. Buckley, Yohan Chan, A. John Blacker, “Preparation of C2-symmetric biaryl bisiminium salts and their use as organocatalysts for asymmetric epoxidation,” SYNLETT., 2016, 27, 126-130 (DOI10.1055/s-0035-1560540)

75. Emma L. Watson, Antony Ball, Steven A. Raw, Stephen P. Marsden, “Synthetic studies on Psychotrimine: Palladium-catalysed arylation of 2-(N-indolyl) amides,” SYNLETT., 2016, 27, 146-150 (DOI: 10.1055/s-0035-1560519)

2015

74. A. John Blacker* and Katherine E. Jolley, "Continuous formations of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors," BEILSTEIN J. ORG. CHEM., 2015, 11, 2408-2417 (DOI: 10.3762/bjoc.11.262)

73. Paul B. J. Thompson*, Bao N. Nguyen, Rachel Nicholls, Richard A. Bourne, John B. Brazier, Kevin R. J. Lovelock, Simon D. Brown, Didier Wermeille, Oier Bikondoa, Christopher A. Lucas, Thomas P. A. Hase and Mark A. Newton*, “X-ray spectroscopy for chemistry in the 2-4keV energy regime at the XMaS beamline: ionic liquids, Rh and Pd catalysts in gas and liquid environments, and Cl contamination in γ-Al2O3,” J. SYNCHROTRON RAD., 2015,  22, 1426-1439 (DOI: 10.1107/S1600577515016148)

72. Michael R. Chapman,  Yarseen M. Shafi, Nikil Kapur,* Bao N. Nguyen* and Charlotte E. Willans*, “Electrochemical flow-reactor for expedient synthesis of copper–N-heterocyclic carbene complexes,” CHEM. COMMUN., 2015, 51, 1282-1284 (DOI: 10.1039/C4CC08874C)

71. John Leonard, A. John Blacker, Stephen P. Marsden, Martin F. Jones, Keith R. Mulholland, and Rebecca Newton, “A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates,” ORG. PROCESS RES. DEV., 2015, 19 (10), 1400–1410 (DOI: 10.1021/acs.oprd.5b00199)

70. Grant J. Sherborne, Bao N. Nguyen*, "Recent XAS Studies into Homogeneous Metal Catalyst in Fine Chemical and Pharmaceutical Syntheses," CHEM. CENT. J., 2015, 9, 37 (DOI: 10.1186/s13065-015-0103-6).

69. Michael R. Chapman,  Benjamin R. M. LakeChristopher M. Pask,  Bao N. Nguyen and  Charlotte E. Willans* “Solid-state structure, solution-state behaviour and catalytic activity of electronically divergent C,N-chelating palladium–N-heterocyclic carbene complexes,” DALTON TRANS., 2015, 44, 15938-15948 (DOI: 10.1039/C5DT02194D)

68. Grant J. SherborneMichael R. ChapmanA. John BlackerRichard A. BourneThomas W. ChamberlainBenjamin D. CrossleyStephanie J. LucasPatrick C. McGowanMark A. NewtonThomas E. O ScreenPaul ThompsonCharlotte E. Willans, and Bao N. Nguyen*, “Activation and Deactivation of a Robust Immobilized Cp*Ir-Transfer Hydrogenation Catalyst: A Multielement in Situ X-ray Absorption Spectroscopy Study,”J. AM. CHEM. SOC., 2015, 137 (12), pp 4151–4157 (DOI: 10.1021/ja512868a)

67. christopher A. Hone, Richard A. Bourne, Frans L. Muller*, “Continuous-flow reactors for the rapid evolution and validation of kinetic motifs,” CHIM. OGGI, 2015, 33 (4), 14-20 (link)

66. Vasuki Ramachandran, Darragh Murnane, Robert B. Hammond, Jonathan Pickering, Kevin J. Roberts, Majeed Soufian, Ben Forbes, Sara Jaffari, Gary P. Martin, Elizabeth Collins, and Klimentina Pencheva, “Formulation Pre-screening of Inhalation Powders Using Computational Atom–Atom Systematic Search Method,” MOL. PHARMACEUTICS, 2015, 12 (1), pp 18–33 (DOI: 10.1021/mp500335w)

65. Diana M. CamachoKevin J. Roberts*Ken LewtasIain More, “The crystal morphology and growth rates of triclinic N-docosane crystallising from N-dodecane solutions,” J. CRYST. GROWTH, 2015, 416, 47-56 (DOI:10.1016/j.jcrysgro.2015.01.006)

64. D. Toroz,*   I. Rosbottom,   T. D. Turner,   D. M. C. Corzo,  R. B. Hammond,  X. Lai and   K. J. Roberts, “Towards an understanding of the nucleation of alpha-para amino benzoic acid from ethanolic solutions: a multi-scale approach,” FARADAY DISCUSS., 2015, 179, 79-114 (DOI: 10.1039/C4FD00275J)

63. I. Rosbottom, K. J. Roberts* and R. Docherty, “The solid state, surface and morphological properties of p-aminobenzoic acid in terms of the strength and directionality of its intermolecular synthons,” CRYSTENGCOMM, 2015, 17, 5768–5788 (DOI: 10.1039/C5CE00302D)

62. Bao N. Nguyen, Luis A. Adrio, Tim Albrecht, Andrew J. P. White, Mark A. Newton, Maarten Nachtegaal, Santiago J. A. Figueroa, King K. (Mimi) Hii, "Electronic structures of cyclometalated palladium complexes in the higher oxidation states", DALTON TRANS., 2015, 15938-15948 (DOI: 10.1039/C5DT02104A).

61. S. R. Chauruka, A. Hassanpour, R. Brydson, K. J. Roberts, M. Ghadiri, H. Stitt, “Effect of mill type on the size reduction and phase transformation of gamma alumina,” CHEM. ENG. SCI., 2015, 134, 774-783 (DOI:10.1016/j.ces.2015.06.004).

2014

60. Rachel L. Nicholls, C. M. Pask, B. Nguyen, "Crystal structure of poly [m-acetato-bis­[-2-oxo-2-(quinolin-8-yl)ethano­ato]tris­odium]," ACTA CRYST., 2014, E70, m385-m386 (DOI: 10.1107/S1600536814023423).

59. Sambiagio, C., Munday, R. H., Marsden, S. P., Blacker, A. J. and McGowan, P. C., “Picolinamides as Effective Ligands for Copper-Catalysed Aryl Ether Formation: Structure–Activity Relationships, Substrate Scope and Mechanistic Investigations,” CHEM. EUR. J., 2014, 20, 17606–17615. (DOI:10.1002/chem.201404275)

58. Rachel L. Nicholls, Simon Kaufhold, Bao N. Nguyen*, “Observation of guanidine-carbon dioxide complexation in solution and its role in the reaction of carbon dioxide and propargylamines,” CATAL. SCI. TECHNOL., 2014, 4, 3458-3462 (DOI: 10.1039/C4CY00480A)

57. Andrea Rodríguez-Bárzano, Joel D. A. Fonseca, A. John Blacker and Patrick C. McGowan*, “Ruthenium Halide Complexes as N-Alkylation Catalysts,” EUR. J. INORG. CHEM., 2014, 1974–1983 (DOI: 10.1002/ejic.201400117)

56. Carlo Sambiagio,*  Stephen P. Marsden,  A. John Blacker and  Patrick C. McGowan*, “Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development,” CHEM. SOC. REV., 2014, 43, 3525-3550 (DOI: 10.1039/C3CS60289C)

55. Thomas W. Chamberlain,*  James H. EarleyDaniel P. Anderson,  Andrei N. Khlobystov and  Richard A. Bourne* “Catalytic nanoreactors in continuous flow: hydrogenation inside single-walled carbon nanotubes using supercritical CO2,” CHEM. COMMUN., 2014, 50, 5200-5202 (DOI: 10.1039/C3CC49247H)

54. Nicola J. Webb, Stephen P. Marsden,* and Steven A. Raw, “Rhodium(III)-Catalyzed C−H Activation/Annulation with Vinyl Esters as an Acetylene Equivalent,” ORG. LETT., 2014, 16, 4718−4721 (DOI: 10.1021/ol502095z)

53. Ainara Nova, David J. Taylor, A. John Blacker, Simon B. Duckett, Robin N. Perutz, and Odile Eisenstein, “Computational Studies Explain the Importance of Two Different Substituents on the Chelating Bis(amido) Ligand for Transfer Hydrogenation by Bifunctional Cp*Rh(III) Catalysts,” ORGANOMETALLICS, 2014, 33 (13), 3433–3442 (DOI: 10.1021/om500356e)

52. Zhi-Peng Lan, Xiaojun Lai, Kevin Roberts, and Helmut Klapper, “X-ray Topographic and Polarized Optical Microscopy Studies of Inversion Twinning in Sodium Chlorate Single Crystals Grown in the Presence of Sodium Dithionate Impurities,” CRYSTAL GROWTH & DESIGN, 2014, 14 (11), 6084–6092 (DOI: 10.1021/cg5012428)

51. T. T. H. Nguyen, R. B. Hammond K. J. Roberts,*  I. Marziano and G. Nichols, “Precision measurement of the growth rate and mechanism of ibuprofen {001} and {011} as a function of crystallization environment,” CRYSTENGCOMM, 2014, 16, 4568-4586, (DOI: 10.1039/C4CE00097H)

50. D. M. Camacho Corzo, A. Borissova, R. B. Hammond, D. Kashchiev, K. J. Roberts, K. Lewtas, and I. More, Nucleation mechanism and kinetics from the analysis of polythermal crystallisation data: Methyl stearate from kerosene solutions.” CRYSTENGCOMM, 2014, 16 (6). 974 - 991. (DOI: 10.1039/C3CE41098F)

49. J. B. Brazier, Bao N. Nguyen, Luis A. Adrio, E. M. Barreiro, W. P. Leong, M. A. Newton, Santiago J. Figueroa, Klaus Hellgardt, King Kuok Mimi Hii,"Catalysis in Flow: Operando Study of Pd Catalyst Speciation and Leaching", CAT. TODAY2014, 229, 95-102 (DOI: 10.1016/j.cattod.2013.10.079).

48. A. Kwokal and K. J. Roberts, “Direction of the polymorphic form of entacapone using an electrochemical tuneable surface template,” CRYSTENGCOMM, 2014, 16, 3487-3493 (DOI: 10.1039/C3CE42473A)

47. D. Toroz, R. B. Hammond, K. J. Roberts, S. Harris, T. Ridley, “Molecular Dynamics simulations of organic crystal dissolution: The lifetime and stability of the polymorphic forms of para-amino benzoic acid in aqueous environment.” J. CRYSTAL GROWTH, 2014, 401, 38-43 (DOI: 10.1016/j.jcrysgro.2014.01.064)

2013

46. Mohamed M. Farah; Philip C. Bulman PageBenjamin R. BuckleyA. John Blacker and Mark R.J. Elsegood, “Novel biphenyl organocatalysts for iminium ion-catalyzed asymmetric epoxidation,” TETRAHEDRON, 2013, 69, 758-769 (DOI:10.1016/j.tet.2012.10.076)

45. Stephanie J. Lucas,  Benjamin D. Crossley,  Alan J. Pettman,  Antony D. Vassileiou,  Thomas E. O. ScreenA. John Blacker and   Patrick C. McGowan*,  “A robust method to heterogenise and recycle group 9 catalysts,” CHEM. COMMUN., 2013, 49, 5562-5564 (DOI: 10.1039/C3CC42550A)

44. Andrea Rodríguez-Bárzano, A. John Blacker and Patrick C. McGowan*, ”Synthesis and characterisation of tetramethylfulvene complexes of ruthenium,” DALTON TRANS., 2013, 42, 16669 (DOI: 10.1039/c3dt52747f)

43. Ana Kwokal, Dražen Čavužić, and Kevin J. Roberts*, “Surface Adsorbed Templates for Directing the Crystal Growth of Entacapone as Monitored Using Process Analytical Techniques,” CRYSTAL GROWTH & DESIGN, 2013, 13 (12), pp 5324–5334 (DOI: 10.1021/cg401188c)

42. John Blacker, “Right First Time in Fine-Chemical Process Scale-Up: Avoiding ScaleUp Problems: The Key to Rapid Success,” ORG. PROCESS RES. DEV., 2013, 17, 1214−1215 (DOI: 10.1021/op400176g)

41. Syarifah Abd Rahim, Robert B. Hammond, Ahmad Y. Sheikh and Kevin J. Roberts,* "A comparative assessment of the influence of different crystallization screening methodologies on the solid forms of carbamazepine co-crystals," CRYSTENGCOMM., 2013, 15, 3862-3873 (DOI: 10.1039/C3CE26878K

40. Ravendra Singh, Andy Godfrey, Björn Gregertsen, Frans Muller, Krist V. Gernaey, Rafiqul Gani, John M. Woodley, “Systematic substrate adoption methodology (SAM) for future flexible, generic pharmaceutical production processes,” COMPUT. CHEM. ENG., 2013, 58, 344-368 (doi:10.1016/j.compchemeng.2013.07.010)

39. F. L. Muller “How green is your engineering proposal? Life cycle impact assessment in High Value Chemical Manufacturing,” CHIM. OGGI, 2013, 31, 34-38 (link)

 

2012

38. Nornizar Anuar, Wan Ramli Wan Daud, Kevin J. Roberts, Siti KartomKamarudin, and Siti Masrinda Tasirin, “Morphology and Associated Surface Chemistry of l-Isoleucine Crystals Modeled under the Influence of l-Leucine Additive Molecules,” CRYSTAL GROWTH & DESIGN, 2012, 12 (5), 2195–2203 (DOI: 10.1021/cg200266e)

37. Robert B. Hammond, Klimentina Pencheva and  Kevin J. Roberts*, “Structural variability within, and polymorphic stability of, nano-crystalline molecular clusters of L-glutamic acid and D-mannitol, modelled with respect to their size, shape and ‘crystallisability’,” CRYSTENGCOMM, 2012, 14, 1069-1082 (DOI: 10.1039/C1CE06174G)

36. John P. Cooksey*, Philip J. Kocieński*, Arndt W. Schmidt, Thomas N. Snaddon, Colin A. Kilner, “A Synthesis of the Pseudopterosin A–F Aglycone,” SYNTHESIS, 2012, 44(17), 2779-2785 (DOI: 10.1055/s-0032-1316643)

35. Krzysztof Jarowicki, Philip Kocieński*, Zofia Komsta, Anna Wojtasiewicz, “Copper(I)-Mediated 1,2-Metallate Rearrangements of 1-Metallated Glycals,” SYNTHESIS, 2012, 6, 946-952  (DOI: 10.1055/s-0031-1289721)

2011

34. Shahid Khan, Cai Y. Ma, Tariq Mahmud,* Radoslav Y. Penchev, Kevin J. Roberts, Julian Morris, Leyla Ozkan, Graeme White, Bruce Grieve and Alan Hall, Paul Buser, Neil Gibson, Patrik Keller, Paul Shuttleworth, Christopher J. Price, “In-Process Monitoring and Control of Supersaturation in Seeded Batch Cooling Crystallisation of L-Glutamic Acid: From Laboratory to Industrial Pilot Plant,” ORG. PROCESS RES. DEV., 2011, 15, 540–555 (DOI: 10.1021/op100223a)

33. David R Merrifield, Vasuki Ramachandran, Kevin J Roberts, Wesley Armour, Danny Axford, Mark Basham, Thomas Connolley, Gwyndaf Evans, Katherine E McAuley, Robin L Owen and James Sandy, “A novel technique combining high-resolution synchrotron x-ray microtomography and x-ray diffraction for characterization of micro particulates,” MEAS. SCI. TECHNOL., 2011, 22, 115703-115715 (DOI:10.1088/0957-0233/22/11/115703)

32. Haque, J. N., Mahmud, T., Roberts, K. J., Liang, J. K., White, G., Wilkinson, D. and Rhodes, D., “Free-surface turbulent flow induced by a Rushton turbine in an unbaffled dish-bottom stirred tank reactor: LDV measurements and CFD simulations,” CAN. J. CHEM. ENG., 2011, 89, 745–753. (DOI: 10.1002/cjce.20599)

31. Yingfa Li, John P. Cooksey, Zhanghua Gao, Philip J. Kocieński*, Stephen M. McAteer, Thomas N. Snaddon, “A Formal Synthesis of Ionomycin Featuring a Permanganate-Mediated Oxidative Cyclisation,” SYNTHESIS, 2011, 1, 104-108 (DOI: 10.1055/s-0030-1258327)

30. Robert B. Hammond,* Vasuki Ramachandran and  Kevin J. Roberts, “Molecular modelling of the incorporation of habit modifying additives: α-glycine in the presence of L-alanine,”  CRYSTENGCOMM, 2011, 13, 4935-4944 (DOI: 10.1039/C0CE00910E)

29. Xiaojun Lai,* Kevin J. Roberts,  Joakim Svensson and  Graeme White, “Reaction calorimetric analysis of batch cooling crystallization processes: studies of urea in supersaturated water–methanol solutions,” CRYSTENGCOMM, 2011, 13, 2505-2510 (DOI: 10.1039/C0CE00786B)

 

2010

28. Ourida SaidiMark J. BamfordA. John BlackerJames LynchStephen P. MarsdenPawel PlucinskiRobert J. WatsonJonathan M.J. Williams*, “Iridium-catalyzed formylation of amines with paraformaldehyde,” TETRAHEDRON LETT., 2010, 51 (44), 5804-5806 (DOI: 10.1016/j.tetlet.2010.08.106)

27. Matthew McConville, John Blacker, Jianliang Xiao*, “Heck Reaction in Diols and Cascade Formation of Cyclic Ketals,” SYNTHESIS, 2010, 2, 349-360 (DOI: 10.1055/s-0029-1217139)

26. Ourida Saidi,  A. John Blacker,  Mohamed M. Farah,  Stephen P. Marsden and   Jonathan M. J. Williams*, “Iridium-catalysed amine alkylation with alcohols in water,” CHEM. COMMUN., 2010, 46, 1541-1543 (DOI: 10.1039/B923083A)

25. Matthew McConville,  Jiwu RuanJohn Blacker and  Jianliang Xiao*, “Synthesis of oxygen heterocycles by regioselective Heck reaction,” ORG. BIOMOL. CHEM., 2010, 8, 5614-5619 (DOI: 10.1039/C0OB00508H)

24. Ourida Saidi, A. John Blacker, Gareth W. Lamb, Stephen P. Marsden, James E. Taylor, and Jonathan M. J. Williams* , “Borrowing Hydrogen in Water and Ionic Liquids: Iridium-Catalyzed Alkylation of Amines with Alcohols,”ORG. PROCESS RES. DEV., 2010, 14, 1046–1049 (DOI: 10.1021/op100024j)

23. John P. Cooksey, Rhonan Ford, Philip J. Kocieński*, Beatrice Pelotier, Jean-Marc Pons, “A synthesis of (−)-ebelactones A and B,” TETRAHEDRON, 2010, 66, 6462-6467 (DOI:10.1016/j.tet.2010.05.072)

22. Fiona J. Black and   Philip J. Kocienski*, “Synthesis of phalluside-1 and Sch II using 1,2-metallate rearrangements,” ORG. BIOMOL. CHEM.,  2010, 8, 1188-1193 (DOI: 10.1039/B920285D)

21. Valera, FernandoE., Quaranta, M., Moran, A., Blacker, J., Armstrong, A., Cabral, JoãoT. and Blackmond, DonnaG., “The Flow’s the Thing…Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow,” ANGEW. CHEM. INT. ED., 2010, 49, 2478–2485. (DOI:10.1002/anie.200906095)

20. Dagmar C. Kapeller*, Philip J. Kocienski*, “2-Benzothiazolyl Propargyl Sulfides: Versatile Precursors for Enantiopure Allenes, E-α,β-Unsaturated Ketones and Z-Sulfonylalkenes,” SYNTHESIS, 2010, 22, 3811-3821  (DOI: 10.1055/s-0030-1258259)

19. A. Borissova, G. E. Goltz, J. P. Kavanagh, T. A. Wilkins, “Reverse engineering the kidney: modelling calcium oxalate monohydrate crystallization in the nephron,” MED. BIO. ENG. COMPUT., 2010, 48 (7), 649-659 (DOI: 10.1007/511517-010-0617-y)

18. Kashchiev D, Borissova A, Hammond RB, Roberts KJ., “Dependence of the critical undercooling for crystallization on the cooling rate.” J. PHYS CHEM B., 2010, 114 (16), 5441-6. (DOI: 10.1021/jp100202m)

17. Dimo Kashchiev*, Antonia Borissova, Robert B. Hammond, Kevin J. Roberts, “Effect of cooling rate on the critical undercooling for crystallization,” J. CRYSTAL GROWTH, 2010, 312 (5), 698-704 (DOI:10.1016/j.jcrysgro.2009.12.031)

2009

16. A. John BlackerMohamed M. FarahStephen P. Marsden*Ourida SaidiJonathan M.J. Williams, “Oxidative conversion of amines into benzoxazoles using hydrogen transfer catalysis,” TETRAHEDRON LETT., 2009, 50 (45), 6106-6109 (DOI:10.1016/j.tetlet.2009.08.042)

15. Ana Kwokal,* Thai T. H. Nguyen, and Kevin J. Roberts, “Polymorph-Directing Seeding of Entacapone Crystallization in Aqueous/ Acetone Solution Using a Self-Assembled Molecular Layer on Au (100),”  CRYSTAL GROWTH & DESIGN, 2009, 9 (10), 4324-4334 (DOI: 10.1021/cg900105u)

14. A.John Blacker,* Stuart Brown, Blandine Clique, Brian Gourlay, Catherine E. Headley, Stephen Ingham, Dougal Ritson, Thomas Screen, Matthew J. Stirling, David Taylor, and Gary Thompson, “A Low-Waste Process To Sertraline By Diastereomeric Crystal Resolution and Waste Isomer Racemisation,” ORG. PROCESS RES. DEV.,  2009, 13, 1370-1378 (DOI: 10.1021/op900112f)

13. A. John Blacker,* Mohamed M. Farah, Michael I. Hall, Stephen P. Marsden,* Ourida Saidi, and Jonathan M. J. Williams*, “Synthesis of Benzazoles by Hydrogen-Transfer Catalysis,” ORG. LETT., 2009, 11, 2039-2042 (DOI: 10.1021/ol900557u)

12. Ourida Saidi Dr., A.John Blacker Prof., MohamedM. Farah Dr., StephenP. Marsden Prof., JonathanM.J. Williams Prof. “Selective Amine Cross-Coupling Using Iridium-Catalyzed “Borrowing Hydrogen” Methodology,” ANGEW. CHEM. INT. ED., 2009, 48, 7375–7378 (DOI: 10.1002/anie.200904028)

11. Zhanghua Gao, Yingfa Li, John P. Cooksey, Thomas N. Snaddon, Stefan Schunk, Eddy M. E. Viseux, Stephen M. McAteer, and Philip J. Kocienski*, “A Synthesis of an Ionomycin Calcium Complex,” ANGEW. CHEM. INT. ED., 2009, 48, 5022 –5025 (DOI: 10.1002/anie.200901608)

10. Emma  L. Watson, Stephen P. Marsden*, Steven A. Raw, “A robust, efficient catalyst system for enolate arylation leading to quaternary 3-aminooxindoles,” TETRAHEDRON LETT., 2009, 50, 3318-3320 (DOI:10.1016/j.tetlet.2009.02.076)

9. Zeng-Ping Chen, Julian Morris, Antonia Borissova, Shahid Khan, Tariq Mahmud, Rado Penchev, Kevin J. Roberts, “On-line monitoring of batch cooling crystallization of organic compounds using ATR-FTIR spectroscopy coupled with an advanced calibration method,” CHEMOMETR. INTELL. LAB., 2009, 96 (1), 49-58 (DOI:10.1016/j.chemolab.2008.11.002).

8. Antonia Borissova, Shahid Khan, Tariq Mahmud*, Kevin J. Roberts, John Andrews, Paul Dallin, Zeng-Ping Chen and Julian Morris, “In Situ Measurement of Solution Concentration during the Batch Cooling Crystallization of l-Glutamic Acid using ATR-FTIR Spectroscopy Coupled with Chemometrics,” CRYST. GROWTH DES., 2009, 9 (2), pp 692–706. (DOI: 10.1021/cg7010265)

2008

7. Spoorthi Dharmayat, Robert B. Hammond,* Colin Kilner, Xiaojun Lai, Rex A. Palmer, Brian S. Potter, Christopher M. Rayner, and Kevin J. Roberts, “Comparison of the Crystal Chemistry, the Process Conditions for Crystallization and the Relative Structural Stability of Two Polymorphic Forms of NG-monomethyl-L-arginine Hydrochloride,” ORG. PROCESS RES. DEV., 2008, 12, 860–868 (DOI: 10.1021/op700171b)

6. Gilbert Besong, Denis Billen, Indu Dager, Philip Kocienski*, Eric Sliwinski, Lik Ren Tai, F. Thomas Boyle, “A synthesis of (aR,7S)-(−)-N-acetylcolchinol and its conjugate with a cyclic RGD peptide,” TETRAHEDRON, 2008, 64, 4700-4710 (DOI:10.1016/j.tet.2008.01.130)


5. Krzysztof Jarowicki, Colin Kilner, Philip J. Kocienski*, Zofia Komsta, Jacqueline E. Milne, Anna Wojtasiewicz, Victoria Coombs, “A Synthesis of 1-Lithiated Glycals and 1-Tributylstannyl Glycals from 1-Phenylsulfinyl Glycals via Sulfoxide-Lithium Ligand Exchange,” SYNTHESIS, 2008, 17, 2747-2763  (DOI: 10.1055/s-2008-1067226)

4. Cai Y. Ma, Xue Z. Wang, and Kevin J. Roberts, “Morphological Population Balance for Modeling Crystal Growth in Face Directions,” AIChE JOURNAL, 2008, 54(1), 209-222 (DOI: 10.1002/aic.11365)

3. Rui Fa Li, Radoslav Penchev, Vasuki Ramachandran, Kevin J. Roberts,* Xue Z. Wang, Richard J. Tweedie, Andy Prior, Jan W. Gerritsen, and Fred M. Hugen, “Particle Shape Characterisation via Image Analysis: from Laboratory Studies to In-process Measurements Using an in Situ Particle Viewer System,”  ORG. PROCESS RES. DEV., 2008, 12, 837–849 (DOI: 10.1021/op800011v)

2. Xue Z. Wang, Kevin J. Roberts, Caiyun Ma, “Crystal growth measurement using 2D and 3D imaging and the perspectives for shape control,” CHEMICAL ENGINEERING SCIENCE, 2008, 63, 1173 – 1184 (DOI: 10.1016/j.ces.2007.07.018)

1. Yi-Xia Jia, J. Mikael Hillgren, Emma L. Watson, Stephen P. Marsden and E. Peter Kundig*, “Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis,” CHEM. COMMUN., 2008, 4040–4042 (DOI: 10.1039/B810858G)

 

Books

John Blacker, Michael T Williams, Pharmaceutical Process Development : Current Chemical and Engineering Challenges, ed. John Blacker, Michael T Williams, RSC publishing, Cambridge, 2011 (DOI:10.1039/9781849733076)

Book Chapters

Benjamin R. M. Lake, Michael R. Chapman and Charlotte E. Willans, "N-heterocyclic carbenes; partakers not just spectators." Organometallic Chemistry, 2016, 40, 107-139, RSC publishing, Cambridge (DOI: 10.1039/9781782623960-00107)

A. John Blacker, Jessica R. Breen, Richard A. Bourne and Christopher A. Hone, “The Growing Impact of Continuous Flow Methods on the Twelve Principles of Green Chemistry,”  Green and Sustainable Medicinal Chemistry : Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, ed. L. Summerton, H. F. Sneddon, L. C. Jones, J. H. Clark, RSC publishing, 2016, (DOI: 10.1039/9781782625940)

Nicholas Holmes and Richard Bourne, Chemical Processes for a Sustainable Future, ed. Trevor Letcher, Janet Scott, Darrell Patterson, RSC publishing, 2015 (ISBN: 978-1-84973-975-7)


John Blacker and Catherine E. Headley, “Dynamic resolution of chiral amine pharmaceuticals: turning waste isomers into useful product,” Green Chemistry in the Pharmaceutical Industry, ed. Peter J. Dunn, Andrew S. Wells, Michael T. Williams, Wiley-VCH, 2010, 269-288.