Institute of Process Research and Development

News and events

Viva success

25th August 2017

Congratulations to Lisa Thompson on the completion of her PhD by successfully defending her thesis. Lisa's research with John Blacker was on the combination of organometallic and biological catalysts in the synthesis of chiral amines in continuous flow reactors.

Lisa is continuing as a her research as a postdoctoral researcher with Kylie Vincent at the University of Oxford.

Well done Lisa!

Viva success

22nd August 2017

Congratulations to Rachel Nicholls for the successful defense of her thesis on novel processes to react carbon dioxide with biomass-based chemicals. Rachel carried out her research with Bao Nguyen. Her research was sponsored by the EPSRC.

Well done Rachel - all the best for the future from iPRD!

ACS Editor's Choice Article

20th July 2017

A recent OPRD paper about iPRD's mini-CSTRs, called Freactors was selected as an ACS Editor's Choice article. Each day scientific editors of ACS journals from around the world select one new article from the entire ACS journal portfolio to feature as their editor's choice and this article was chosen due to its broad public interest. The articles remain open for all the access and read. The paper was written in collaboration with researchers from Nick Turner's group at the University of Manchester as well as a number of members of the iPRD.

The Freactors are 2 ml CSTRs which are modular and flexible and for small lab-scale reactions, allowing researchers to test out continuous flow conditions, without using large quantities of valuable starting materials. They are designed for multi-phasic reactions and the paper describes their use in liquid-liquid, liquid-solid and gas-liquid-solid reactions. They have been used for a range of different reactions including enzyme catalysed ad metal-catalysed reactions. You can read the paper here. To find out how we've been using the Freactors or if you have any stories of your own visit our Freactor blog here.

Viva success

4th July 2017

Congratulations to James McManus on the completion of his PhD by sucessfully defending his thesis. James' research with John Blacker was on combined organo/organometallic catalysis for the synthesis of unsymmetrical diols. It was funded by an EPSRC supported DTA.

James is continuing as a post-doctural researcher with John Blacker working on copper catalysed C-H activation reactions.

Well done James!

Poster prize

29th June 2017

Congratulations to Rebecca Stones who won a prize for her poster "Investigating the relationship between structure and performance in carbon nanoreactor supported nanoparticle catalysts" at the northern regional meeting for the Dalton Division of the RSC. Rebecca's posters was one of three winners chosen from the 60 posters on display. The meeting was held at the University of Sheffield and gave the opportunity for local PhD and postdoctoral researchers to present their research in the field of inorganic chemistry with over 100 delegates attending.

Becky, a second PhD student from iPRD presented her poster on her work with supervisor Tom Chamberlain on the encapsulation of metal nanoparticles in graphitised carbon nanofibres and their use as hydrogenation catalaysts. For more the conference visit the Univerisity of Sheffields article here and the RSCs website here. To find out more about the research visit Tom's webpages here.

CP3 CDT annual visit to iPRD

28-30th June 2017

The first year CDT students from the complex particulates, products and processes CDT based in chemical engineering came to do their annual experiment in the large scale lab. This gives them a chance to be trained in large scale glassare but also see some of the complications and differences between large scale and small scale processing in crystallisation reactions. They spent two days doing a crystallisation and filtering the end product to see if the correct polymorph had been made.

Fun was had by all!

Viva success

26th May 2017

Congratulations to Nick Holmes for the successful pass of his PhD viva today. Nick carried out his PhD with Richard Bourne and John Blacker and is the first PhD student to finish out of the Bourne group. His PhD research was on the self-optimisation of continuous and segmented flow reactions for rapid process development and was funded by AZ and the iPRD CDT in chemical process engineering.

Well done Nick!

Emerging Investigator

10th April 2017

Richard Bourne has been named as an emerging investigator by the RSC's journal Reaction Chemistry and Engineering. The editors, Saif Khan, Klavs Jensen and Ian Baxendale selected the emerging investigators from early career researchers who are recognised to be carrying out world recognised leading research. The selections were based upon recommendations from senior scientists in both industry and academia. In the article they highlight Rich's research into continuous flow, automation and optimisation and industrial process development.

Read the article here.

Well done Rich!

Viva success

January 2017

Congratulations to Andrew Shier on the successful completion of his PhD viva. Andy did his PhD research on the particle breakage of fresh crystals under presure filtration with supervisors Frans Muller and Kevin Roberts. His PhD was funded by the EPSRC through the chemical process engineering CDT which also included an MSc year at the start. He is continuing his career as a chemical engineer at Pfizer in Sandwich, Kent.

Well done and all the best for the future Andy!

Prize winning postdocs!

16th December 2016

Three iPRD postdocs won prizes at the second postdoc conference for the School of Chemistry: Claudio Avila was awarded runner up prize for his talk on the developments of fast and low-cost near infrared-red sensor for online process monitoring, particularly for his use of real-time commentary of the data collections played during the presentation; Faiz Mahdi won the top prize in the poster session, for his poster, discussion and flash presentation entitled “Novel Inline Particle Sizing Sensor for Process Control ‑ ProPAT” and Alastair Baker was awarded runner up for his poster and discussion on valorisation of bioethanol using an automated flow reactor at high temperature and pressure.

The conference was organised by a committee of postdocs who did at fantastic job at providing a varied and balanced program, including talks by the newly appointed UAFS to present their research and areas for potential collaborations within the department. The talks were followed by the department Christmas drinks to give a great day which was enjoyed by all. Well done to all the speakers and presenters for giving us a great day with lots of great science!

Congratulations Claudio, Faiz and Alastair!


Viva success!

7th November 2016

Congratulations to Michael Chapman who successfully defended his thesis on metal complexes of N-heterocyclic carbenes generated using electrochemical flow methods with Dr Charlotte Willans and Dr Bao Nguyen of iPRD. His PhD was funded by the iPRD CDT where he also carried out an MSc in Chemical Process Engineering. Mike is continuing his research career in iPRD doing postdoctoral research for John Blacker investigation biooxidative transformations in continuous flow reactors.

Well done Mike!

iPRD research on Reaction Chemistry and Engineering Cover

27th July 2016

Self-optimisation research from Richard Bourne's group in iPRD was highlighted by the RSC journal Reaction Chemistry and Engineering using a cover designed by one of our final year PhD students, Nick Holmes.

The work involved the use of an automated flow reactor and feedback algorithms to rapidly optimise the final step in the synthesis of AZD9291, a EGFR kinase inhibitor developed by AstraZeneca. Proof-of-concept on a model compound allowed impurity formation to be tracked and gave mechanistic understanding to the reactions occurring. By using at-line HPLC and evolutionary algorithms, the reaction can be optimised quickly, minimising the time and resource costs often required using one-variable-at-a-time and design-of-experiment optimisation approaches. In addition, the team included material minimisation steps to reduce waste of costly starting materials and rapid cooling reduced the time between experiments.

To find out more information about the research, the paper can be accessed here.

Postgraduate Conference 2016

13th June 2016

Congratulations to Michael Chapman and Grant Sherbourne, third year PhD students in iPRD who won prizes for their talks at the annual School of Chemistry postgraduate conference. The conference showcased work from PhD students across the school through posters and presentations with several iPRD members presenting on 9th and 10th June.

The event also featured a careers clinic with members of our Industrial Advisor Board; and, an invited plenary lecture by Jim Baggott, who gave an entertaining showcase of his recent book Origins: The Scientific Story of Creation. The conference concluded with a wine reception and was sponsered by the Royal Society of Chemistry, Merck and Lhasa Ltd.

Well done to all who presented and made the event so enjoyable!

International grant to fund research into sustainable chemical processes

15th April 2016

John Blacker of iPRD has received a $50,000 grant from the American Chemical Society Green Institute (ACS GCI) Pharmaceutical Roundtable. His winning grant proposal is titled, "Process Development of Continuous Flow Oxidative Biotransformations." With this award Blacker will research the use of continuous flow processing methods for biological catalysts that use oxygen, a clean oxidant. Continuous flow refers to a process for making chemical products using a continuous stream of inputs in a small reactor. IT is considered a safer alternative to the traditional method of large-scale batch processes.

"A key aspect of the research is to increase the reaction rates...through a variety of techniques including engineered enzymes, design of appropriate reactors and processes," says Blacker. Working with a cross-disciplinary team consisting of  biologist, chemist and engineer, Blacker hopes their research "will contribute towards greener methods for manufacturing complex organic chemicals."

The roundtable identified priority green engineering research areas for pharmaceutical and fine chemical companies in 2011. The focus of this year's grant awards is to catalyse research in continuous flow chemistry and engineering.

"Flow chemistry/continuous processing have shown great promise in modernising pharmaceutical production methods," says Stefan Koeing, Ph.D., roundtable co-chair and scientist at Genetech in South San Francisco, California. "With these grants, the roundtable is funding cutting-edge methods that advance chemistry within the pharmaceutical industry and make it sustainable over the long-term."

Blacker was one of three awardees. Since 2005, the roundtable has given $1.78 million dollars in research grants to advance the sustainability profile of pharmaceutical processes using green chemistry techniques. The ACS GCI Pharmaceutical Roundtable brings global industry leaders together to catalyse the implementation of green chemistry and engineering. Current memebers include Amgen, AstraZeneca, Boehringer Ingelhein, Bristol-Myers Squibb, Codexis, Eli Lilly and Company, GlaxoSmithKline, Johnson &Johnson, Merck &Co. Inc., Novartis, Pfizer Inc., Roche, Sanofi and ACS GCI. For more information about ACS GCI visit their website.

Impact of continuous flow methods on green chemistry

14th March 2016

A new book chapter written by a team of chemists from iPRD has been published in "Green and sustainable medicinal chemistry: methods, tools and strategies for the 21st century pharmaceutical industry" by the RSC. The chapter written by John Blacker, Jess Breen, Richard Bourne and Chris Hone is entitled "The growing impact of continuous flow methods on the twelve principles of green chemistry" and discusses less wasteful strategies for synthesising chemical products using flow chemistry strategies. It explores atom economy, avoiding and minimising solvent use, degradation of products at the end of their function so they do not persist in the environment, robust catalyst systems and more.

To read the chapter and the rest of the book visit the RSC website.

Graduation Day

14th December 2015

Congratulations to all of iPRD's latest graduates on graduation day. Here are a couple of pictures from the day.

Viva success!

8th December 2015

Congratulations to (soon-to-be Dr) Mindaugas Paulaskas on the successful defence of his thesis on 8th December. Paul's PhD research focused on the design and development of a graphene oxide membrane reactor for selective water separations - involving the separation of water from organic solvents.  Paul's supervisors were Frans Muller and Charlotte Willans and was sponsored by the EPRSC. As part of his PhD he did an industrial placement at Croda. Paul is off to Germany for his next steps so we wish him all the best in his future endeavors.

A huge well done to Paul from all the iPRD.

Upcoming conference

30th November 2015

We're looking forward to the UK Catalysis Conference in Loughborough on 6-8th January 2016 where Professor John Blacker of iPRD will be giving a plenary lecture entitled "Why does industry struggle to adopt academics' catalysts?". Academic fellow Dr Thomas Chamberlain and PhD students Rachel Nicholls and Grant Sherbourne also of iPRD will also be giving talks at the conference. To find out more about the conference visit their website.

Viva success!

30th November 2015

Congratulations to (soon-to-be Dr) Chris Hone for successfully defending his thesis on 26th November 2015. Chris' PhD investigated the evolution of kinetic models using continous flow technologies and was supervised by Frans Muller, Richard Bourne and Steve Marsden. The research was sponsored by AstraZenenca, where he did a few months placement and the EPRSC. Chris will be continuing his research interests in continuous flow in the group of Oliver Kappe at the University of Graz.

Well done Chris, all the best for the future from iPRD.

First prize

19th November 2015

PhD student Nick Holmes was awarded 1st place poster prize at the 5th Conference on Frontiers of Organic Synthesis Technology (FROST) in Budapest, Hungary. The work entitled Quantitative Mass Spectrometry in Self-Optimizing Flow Reactors for Rapid Process Optimization” was also presented orally on the final day as part of the prize, and was in collaboration with Christian Stanetty and Ian Baxendale from Durham University. Nick is supervised by Richard Bourne and John Blacker and is sponsored by AstraZeneza.

The FROST conference is organized by the flow chemistry society and showcases the latest trends in flow and synthesis technologies. This year's conference featured keynote speakers Rigoberto Advincula (Case Western Reserve Univerisity, Ohio), Holger Löwe (Johannes Gutenberg-University, Mainz) and Walter Leitner (RWTH Aachen) along with other leading researchers from the flow chemistry community. 

Well done Nick!

iPRD Industrial Club day

28th October 2015

Academic and industrial members of the iPRD industrial club met for the biannual  industrial club event at Weetwood Hall. The event consisted of dinner followed by a day of talks and discussions focusing on heterogeneous catalysis. Guest speakers Professor Edman Tsang from Oxford University and Professor David Lennon from the University of Glasgow showcased their research into heterogeneous catalysis and its applications within an industrial setting. A number of iPRD members spoke, including new academic fellows Drs Thomas Chamberlain, Ali Hassanpour and Robert Menzel. The day was rounded off by some of our industrial members who spoke about their companies development and uses of heterogeneous catalysts.

Thanks to all our speakers for a great day!

Design of Experiments: Undergraduate Lab Module Transfer Workshop

16-17th September 2015

The Dial-a-Molecule Grand Challenge Network has been particularly active in promoting the education and deployment of statistical methods in chemical research. Previous events held under this sub-theme of the Network have indicated that although the tools and techniques are widely used in industry, many academics have never exploited them (often because they were never made aware of them during their own training).

Realising the numerous advantages that training in statistical methods such as Design of Experiments (DoE) and Principle Component Analysis (PCA) would offer, Dial-a-Molecule has the vision that every chemistry graduate should have a grounding in the techniques, and an understanding of when to use them appropriately. To advance this vision, Dial-a-Molecule has awarded financial support to Dr Richard Bourne (iPRD) who has worked with Brian Taylor (AstraZeneca) to enable the development of an UG 'Design of Experiements' laboratory module. A proviso of the funding was that the output (i.e. the lab module) was made available to the chemistry departments across the UK, to incorporate into their own laboratory courses as seen fit.

The practical was first run at the University of Leeds during 2015, where both UG (3rd year) and CDT-masters students had the opportunity to take part. It involved carrying out a simple SNAr reaction using flow methodology, which allowed large amounts of data to be generated quickly. Overall, it was a great success, particularly among the students who provided very positive feedback and enjoyed carrying out industrially relevant experiments. Importantly, the practical allowed them to see the value of DoE.

On September the 16th and 17th, Dial-a-Molecule provided partial support for a workshop to begin to roll out the practical to other departments across the UK. As a pilot 'train-the-trainer' event, two representatives from Cardiff University, The University of Strathclyde, The University of Nottingham and Loughborough University attended the workshop.

Day One began with the participants learning about designing and planning the lab module, and how it had been initially implemented at the University of Leeds. It also gave attendees the chance to provide feedback on the barriers that would preclude its inclusion in other institutions, so that these can be addressed before it is rolled out on a larger scale.

After lunch, the participants split up into two groups and became students again, either donning lab coats to perform the lab practical or returning to the classroom to be given an "Introduction to DoE" tutorial. The roles were reversed on the morning of the second day so that the partcipants had the opportunity to experience both the taught and hands-on elements of the course. The afternoon of day two was devoted to analysing the results from the practical sessions, and getting an overview of how to use the MOdde software package.

The feedback from participants was extremely positive and many could see how the practical could be used, or modified slightly to fit their home institutions teaching program. The course developers are currently preparing a manuscript describing the lab module for publication in The Journal of Chemical Education, and hope to run further workshops like the one described above to enable the practical to be carried out at other institutions.

If you are interested in finding out more about the lab module, or if you want to incorporate it into your own institution, please get in touch. Likewise, as the Dial-a-Molecule Network draws to a close they are seeking sponsership to run future workshops - if you are interested please contact them.

Written by Kelly Kilpin from Dial-a-Molecule.

Using continuous flow reactors for the development and validation of kinetic motifs

15th September 2015

Work by Frans Muller, Richard Bourne and Chris Hone from iPRD on the evolution of kinetic motifs using continuous-flow reactors has been published in Chimica Oggi-Chemistry Today.  

The paper describes the concept of using small-scale continuous flow reactors to rapidly collect reaction data whilst using reaction conditions that would be challenging in a batch reactor. The ability to generate large amounts of data rapidly, allows the fitting of kinetic motifs to accurately represent the experiemental data and hence, the process development of organic reactions. They explore the differences between statistical and kinetic approaches towards process development and present case studies demonstrating the use of kinetif motifs.

Producing sugar from landfill waste using industrial biotechnology

28th August 2015

UK based SME, Fiberight Ltd, the Centre for Process Innovation (CPI) and iPRD at the University of Leeds have collaborated as part of an InnovateUK IB Catalyst Late Stage feasibility project. The project will demonstrate optimised enzymatic hydrolysis of Fiberight's high performance cellulose extracted from municipal solid waste, at Demonstration scale, to a repeatable cellulosic sugar which replaces cereal crop for non-food applications.

The 12 month project, which is being led by Fiberight Ltd, will address the IB challenge of "The supply chain for the commodity sugar" a platform feedstock component for IB. The availability of a novel supply chain feedstock which is outside of the food vs fuel and ILUC debate will mitigate climate impact as well as easing supply chain bottlenecks and dependency on foreign import. MSW derived sugar supports UK-IB by offering security of supply from indigenous resources and a stable price point.

The consortium of 7 partners covers the entire supply and value chain with Fiberight contributing proprietary technology and commercial expertise, in collaboration with CPI, a UK Catapult centre which supports SMEs in the translation of IB into commercial processes. Academics from the University of Leeds, Institute of Process Research and Development (iPRD) will provide process control and monitoring expertise. End user application testing of the cellulosic sugar will be provided by UK Biotech SME Rebio Technologies Ltd, via bioethanol production and Aston University, in the production of levulinic acid using heterogeneous catalysts. Two multinational companies will support the project, Knauf in applications testing for bioresin manufacture and Novozymes for the expertise in, and supply of, industrial enzymes. Success in this project will ensure operational excellence in achieving high sugar yield at scale and will up access to waste feedstocks.

A step towards sustainable natural polymers

9th June 2015

Chemists in iPRD have begun work into the development of bio-based chemicals as part of an extensive three year, £3M project led by Biome Bioplastics. The project aims to use lignin, the waste product from the pulp and paper industry, to produce bio-based chemicals on industrial scale. By increasing the availability of these chemicals the prospect of natural polymers which can compete with oil-based polymers economically and functionally could become reality. The development of bio-based chemical feedstocks could also contribute to a more sustainable chemical industry finding applications in fragrances, coatings and personal care products amongst others.

iPRD is part of a consortium with the Universities of Warwick and Liverpool and the Centre for Process Innovation (CPI) working with Biome Bioplastics and are involved in developing scale-up processes to produce the bio-based chemicals on a scale that will allow industrial testing. The project has received support from a number of funding bodies including Biotechnology and Biological Sciences Research Council (BBSRC), Innovate UK and Engineering and Physical Sciences Research Council (EPSRC).

More information about the project can be found on Biome Bioplastics website.

Shining light on catalyst "murder" mystery: the case of the disappearing chlorides

23rd March 2015

A collaborative team of iPRD chemists and beamline scientists at the European Synchrotron Radiation Facility, led by Dr Bao Nguyen, have reported in J. Am. Chem. Soc. a study using synchrotron-based spectroscopic techniques to study the deactivation of a robust immobilised Cp*Ir catalyst for transfer hydrogenation (developed by Yorkshire Process Technology). In contrast to the common practice of focusing on the metal centre, the team employed a holistic approach to investigate the bonding environment around Ir, Cl and K during catalytic turnover.

The slow loss of catalytic activity over time was associated with the loss of chloride ligands from the iridium catalyst. In situ monitoring of the catalyst over time led to the discovery of a concurrent increase in potassium content, which happened as the chloride ligand was replaced with alkoxides to generate a less active Cp*Ir-trialkoxide complex.

Appropriate reactivation strategies have consequently been developed based on these finding to regenerate the catalyst to its original reactivity.

A trip to the House of Commons

9th March 2015

Final year PhD student Christopher Hone from the iPRD was selected to present his work at the SET for Britain event at Westminster. He presented his poster entitled "Process models for high value chemical manufacturing using continuous flow reactors" to expert judges and MPs including Hilary Benn, MP for central Leeds and Shadow Secretary of State for communities and local government who described the participants as "fantastic scientific talent." He is pictured here with all the participants from the School of Chemistry at the University of Leeds.

The SET for Britain competition is organised by the Parliamentary and Scientific Committee alongside the Royal Academy of Engineering, the Royal Society of Chemistry, the Institute of Physics and the Society of Biology. It is designed to support and promote early-career researchers in the fields of science, technology, engineering and mathematics, many of whom will become some Britain's leading figures in science and technology in the future.

To find out more about the event and SET for Britain check out their website.

Another successful viva!

6th March 2015

Congratulations to Dr Peter Baldwin on the successful completion of his PhD viva. Peter did his PhD with John Blacker, Xiaojun Lai and Antonia Borissova on crystallisation induced asymmetric transformation of conglometates using racemisation catalysts. He is now working for Johnson Matthey, a British company for speciality chemicals and sustainable technologies.

A huge well done and best wishes to Pete from all in iPRD.

RAEng Poster Competition

12th February 2015

Andrew Shier, a chemical engineering PhD student in iPRD was selected to represent the University of Leeds at the Royal Academy of Engineering's poster competition during their annual regional lecture. Andy's poster, entitled "Particle Breakage of Fresh Crystals Under Pressure Filtration" was chosen to be in the three posters from the University of Leeds and he presented amongst early-career researchers from the universities of Leeds, Liverpool, Manchester and Sheffield. The event was hosted by Liverpool University's School of Engineering and included a lecture by Paul Howarth FREng and Richard Taylor FREng entitled "The future of civil nuclear research in the UK."

More about this event and the Royal Academy of Engineering can be found here.

Viva success!

6th February 2015

Congratulations to Dr Yuhan Zhao on passing her PhD viva. Yuhan worked with John Blacker on low temperature catalytic hydro-deoxygenation processes of lignin to form aromatic petrochemical monomers.  

A huge well done and best wishes for all her future endeavours go to Yuhan from all the iPRD. 

ProPAT Kick-Off Meeting

27th January 2015

A number of iPRD staff are in Brussels for the kick-off meeting of ProPAT held at the European Commission. Richard Bourne, Frans Muller, Tim Hunter and Ali Hassanpour are part of consortium of industrial and academic members in this significant project which aims to develop novel sensors and analysers for various process parameters including composition, particle size and local bulk properties as well as temperature, flowrate and pressure. They aim to include an integrated process control approach which will assist process development and production in the mineral, ceramic, non-ferrous metals and chemical industries.

To find out more about the project check out their website, here.

New book chapter

13th January 2015 

A book chapter written by Richard Bourne and Nick Holmes has just been published in the RSC's book "Chemical Processes for a Sustainable Future." The book examines the main chemical processes and their impact particularly focusing on the reduction of pollution and maintaining existing resources. It demonstrates ways to lower the cost of producing chemicals and new methodologies chemists are adopting to lower the environmental impact of chemical processes.

More information about the book can be found on the RSC webpage.

Chemistry for Industry Award

18th December 2014

Congratulations to John Blacker who was awarded the SCI Yorkshire and Humber Chemistry for Industry Award. He was presented the award by Joe Sweeney at the University of Huddersfield on 17th December 2014. The award is given to individuals who have used the application of chemistry to enable and support sustainable industrial development in the Yorkshire and Humber region. John's work in the chemical industry and academia have contributed beneficially to several companies in the area. His work in iPRD has enabled at cost support for Yorkshire and Humber SMEs in process research and development and our case studies give some examples of this work.

The award was followed by a lecture by Dr Paul Elliott called "Illuminating Chemistry: The Molecular Manipulation of Light." This is part of a public lecture series, hosted by the University of Huddersfield and included examples from this years chemistry and physics Nobel Prizes as well as Paul's own research.

To find out more about the award visit the SCI website.

Well done John!

Poster prize

15th December 2014

iPRD student Andrew Shier was awarded a poster prize at the Winter Process Chemistry Conference on 11th December for his poster entitled "Particle Breakage of Fresh Crystals Under Pressure Filtration." Andy was one of three iPRD students who were presenting at the conference and his research is funded by the EPRSC and AstraZeneca.

The conference was hosted by Manchester Interdisciplinary Biocentre at Manchester conference centre and included speakers with strong links to industrial process development from both academia and the chemical industry. Presenters included people from chemistry, chemical engineering and biotechnology disciplines. The conference also had a particular focus session on biocatalysis. Further details can be found on the conference website.

First prize!

18th November 2014

Christopher Hone from the Institute of Process Research and Development was awarded First Place Prize for Combined Oral and Poster Presentation Prize at the SCI Early Career Research Meeting in Chester. Chris received the award for his presentation on “Rate-based Experimental Design using Continuous Flow Reactors”. The research is funded by the EPSRC, University of Leeds and AstraZeneca, and involves developing a new approach for the design of scaled-up continuous flow processes from small scale experiments.

The meeting took place on the 6th of November and showcased work from universities and regional science and engineering companies. The event was co-organised by the SCI Process Engineering Group and the SCI Liverpool and North West Section. Second place prize was awarded to Radhika Bava from the University of Chester. The event concluded with the SCI Henry Armstrong Memorial Lecture from Dr Ian Wilson (University of Cambridge) titled “Soft Solids are Hard Work”.

More information about the event can be found here.

First PhD student from the iPRD lab

10th November 2014

Congratulations to Philip Winkworth on passing his viva with a thesis entitled "Towards the synthesis of imines and iminiums and their reactions in situ"

Philip is the first PhD student out of the iPRD lab. He worked with supervisors John Blacker and Steve Marsden on the environmentally benign synthesis of functionalised amines via iridium catalysed hydrogen-borrowing. Funding was provided by Astra Zeneca and the EPSRC which gave him the opportunity to spend 3 months during his PhD at AstraZeneca's site in Macclesfield. Philip is now working as an associate for a pharmaceutical consultancy firm.

iPRD Industrial Club Meeting

29th-30th October 2014 

iPRD members joined industry colleagues for the biannual industrial club meeting in Weetwood Hall. A day of diverse talks covering a number of topics from nuclear processing to crystallisation, continuous flow processing to hydrogen transfer catalysis was followed by discussions on EU funding, potential project ideas and the EPSRC Centre for Doctoral Training in Complex Particulate products and a dinner in Weetwood Hall.

Proof of concept funding

October 2014

Proof of concept funding from the EPSRC Dial-A-Molecule Grand Challenge Network has been awarded to Richard Bourne in collaboration with Nottingham and Bath Universities. They will working on stabilised bimetallic metal nanoparticles in tailor-made carbon nanoreactors as catalysts for continuous-flow biomass vaporisation with supercritical fluids.

New Project

October 2014

Funding for a new project entitled the Evaluation of statistical design for continuous synthesis of pharmaceutical compounds has been given to Richard Bourne in collaboration with AstraZeneca.

Postgraduate Conference 2014

14 July 2014

Congratulations to iPRD prize winners Nic Webb and Dan Foley for talks and Chris Hone for his poster at the annual School of Chemistry Postgraduate Conference on June 18th and 19th.

The School came together for two days of fantastic talks and poster presentations for our 2nd and 3rd year PhD students. Prof David Smith of the University of York delivered the plenary talk and the event was closed by a wine reception then the PG ball the following evening.

Prize winner

8 April 2014

Final year PhD student Nicola Webb won first prize at the SCI regional conference.

Organic chemistry students in the final year of their doctoral studies at UK universities (in synthesis, mechanistic studies, methodology, medicinal chemistry or analysis) were invited to submit applications to present their work at this regional half-day symposia.

Nicola who works in Prof Steve Marsden's group said "My abstract was accepted, along with ten other students from northern universities, and we were given twenty minutes to present our research and answer questions from the audience. I presented a talk called 'Vinyl esters as acetylene equivalents: Rhodium(III)-catalysed C-H activation for the synthesis of isoquinolones and isoquinolines'.

Minister for Universities and Science visits iPRD
January 2013

State of the art facilities for chemistry and chemical engineering in the Institute were showcased during recent a visit by the Rt Hon David Willetts MP.

The minister was given a tour of the Institute of Process Research and Development (iPRD), which aims to bridge the gap between academic research and its application in the chemical and pharmaceutical industries.

Mr Willets said "It is great to see a facility such as this one here at Leeds which is bridging that gap and bringing the benefits of fundamental research to the pharmaceutical and chemical industries.”

Further details are available on the University website

CHEM21  - Chemical manufacturing methods for the 21st century pharmaceutical industries

iPRD scientists and engineers joined colleagues from twelve top European universities, six pharmaceutical companies and four small to medium enterprises to form Europe's largest public-private partnership dedicated sustainable manufacturing of pharmaceuticals. The €26.4 (£21.2M) 4-year project, CHEM21, aims to develop sustainable biological and chemical alternatives to finite materials, such as precious metals, which are currently used as catalysts in the manufacture of medicines.

See the project website for more details